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With the advent of HPLC-MS (mass spectrometry), the opportunity to detect and identify substances at very low concentrations without the require for an isolation stage turned feasible. Whilst this has simplified structure elucidation to a fantastic extent, there are sometimes instances where HPLC-MS by itself is insufficient for full characterizati
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Traditionally, FDA investigators have searched for gross insanitation due to insufficient cleaning and maintenance of equipment and/or inadequate dust Management units. Also, Traditionally speaking, FDA was additional worried about the contamination of nonpenicillin drug products with penicillins or the cross-contamination of drug products and solu
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